To understand and therapeutically modulate the complex responses of neutrophils and monocytes in inflammation associated with autoimmune diseases and cancer.
Mysore V at al. Monocytes transition to monocyte-macrophages within the inflamed vasculature via CCR2 on monocytes and endothelial TNFR2. J. Exp. Med. 2022; May 2;219(5):e20210562. PMID: 35404389. Selected for Journal Cover. Recommended by Faculty Opinions
Mysore V at al. Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens. Med (N Y). 2021 Sep 10;2(9):1050-1071.e7. Selected for Cover image. BWH press release
Mysore V at al. FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity. Nat Commun. 2021 Aug 9;12(1):4791. Selected for Editor’s Highlight Page.
Okubo K at al. Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling. Cell Rep. 2021 May 18;35(7):109142. Selected as Editors’ Pick.
Saggu G at al. Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Nat Commun. 2018 Nov 29;9(1):5058.
Nishi H at al. Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases. J Clin Invest. 2017 Oct 2;127(10):3810-26.